Pioneer of the chemically functionalized glucides
NeTech Inc.



Photo-closslinkable chitosan: KytoGEL

The clinical demands on KytoGEL

"Wound care based on physical adhesion"

  • Ordinary blood products include the coagulant factors of mammalian protein origin. Therefore these are difficult to use to the patients involving vascular disorder or taking anti-blood coagulants.

“Development goal for NeTech

  • is to supply bio-degradable wound dressing that is physically adhesive and can be used in all sorts of situations.

The anxiety of bacterial and fungal infection risks is eliminated from polysaccharides chitosan. Thereby chitosan is promising as a degradable material for wound care.

Applicable materials for wound dressing

Mammalian proteins



Cyanoacrylate Starch
Polyethylene glycol
Thrombin  Polyurethane
Gum Arabic
Collagen Superabsorbent polymer
Sodium Alginate 

Negative factors

Viral infection Low degradability
Low adhesiveness
High cost Toxicity Purification
  Low elasticity  

Characteristic of the chitosan






   Aqueous chitosan: strong acidity

   Difficulty for endotoxin removal

KytoGEL which does not involve chitosan’s weaknesses is a photoreactive polysaccharide.

  • レクチン変換-1.jpgDiminished endotoxin (reverse osmosis water level)
  • レクチン変換-1.jpgNeutral liquid (pH 6~7)
  • レクチン変換-1.jpgHydrogelation and adhesion arising from irradiating ultraviolet-A


  • レクチン変換-1.jpgWe can supply KytoGEL liquid having stabilities of medicine level.

The operation of KytoGEL

Operation of KytoGEL.jpg


Bulk powder

> Shrimp Chitosan (deacetylation: over 90 %)
> White powder of KyteGEL does not smell or gives an slight alcohol smell. 
> The powder of KytoGEL is difficult to dissolve in water and hardly dissolves
    in ethanol.
> The powder absorbs water, swells up, and then becomes viscous liquid.

Physical properties

> KytoGEL liquid converts itself into hydrogel through irradiating UV-A within
    390 nm.
> KytoGEL covalently reacts  to injured  tissue, thereby its hydrogel strongly
    adheres than fibrin glue. 
(Journal of Biomedical Materials Research
    Volume 49(2), 289–295, 2000)

> Hydrogel made by KytoGEL is viscous than fibrin glue.
> Autoclavable
> Stable at room temperature for over one year

> Growth inhibition assay to Escherichia coli, staphylococcus aureus,
    Pseudomonas aeruginosa, hay bacillus and Klebsiella pneumoniae
    indicates the property of antibacterial that is equal to versatile
    methyl paraben.
> Antivirus function develops through the addition of silver-based

Safety data

> Endotoxin: Less than 0.2 EU/mg powder*
     (ordinary use: 1~2 wt% liquid).
> Cytotoxicity: negative*
> Reverse mutation: negative*
> No serological abnormality (rats)
     *Entrusted to Hadano research center institute,
       food and drug safety center


> NeTech supplies the raw materials which guaranteed viscosity,
    photo-reactivity, pH, and stability.

 Animal studies

> KytoGEL is degradable within a month into subcutaneous tissue
    (mouse/rat) and submucosa (pig).
> The validity as hemostat, tissue adhesive, wound healing, topical DDS
    and the like  was proved. 
There are also many clinical study concerning chitosan and a chitosan
      “Chitosan preparations for wounds and burns: antimicrobial and
       wound healing effects” 
Tianhong Dai, et al. Expert Rev Anti Infect
       Ther.  2011; 9(7): 857–879.

LinkIconTopical DDS
LinkIconWound care