Photo-closslinkable chitosan: KytoGEL
The clinical demands on KytoGEL
"Wound care based on physical adhesion"
- Ordinary blood products include the coagulant factors of mammalian protein origin. Therefore these are difficult to use to the patients involving vascular disorder or taking anti-blood coagulants.
“Development goal for NeTech”
- is to supply bio-degradable wound dressing that is physically adhesive and can be used in all sorts of situations.
The anxiety of bacterial and fungal infection risks is eliminated from polysaccharides chitosan. Thereby chitosan is promising as a degradable material for wound care. Mammalian proteins Biodegradable Biocompatible Antibacterial Aqueous chitosan: strong acidity Difficulty for endotoxin removal
Applicable materials for wound dressing
Characteristic of the chitosan
Aqueous chitosan: strong acidity
Difficulty for endotoxin removal
KytoGEL which does not involve chitosan’s weaknesses is a photoreactive polysaccharide.
- Diminished endotoxin (reverse osmosis water level)
- Neutral liquid (pH 6～7)
- Hydrogelation and adhesion arising from irradiating ultraviolet-A
- We can supply KytoGEL liquid having stabilities of medicine level.
The operation of KytoGEL
Specification > KytoGEL liquid converts itself into hydrogel through irradiating UV-A within Safety data
> Shrimp Chitosan (deacetylation: over 90 %)
> White powder of KyteGEL does not smell or gives an slight alcohol smell.
> The powder of KytoGEL is difficult to dissolve in water and hardly dissolves
> The powder absorbs water, swells up, and then becomes viscous liquid.
> KytoGEL covalently reacts to injured tissue, thereby its hydrogel strongly
adheres than fibrin glue. (Journal of Biomedical Materials Research
Volume 49(2), 289–295, 2000)
> Hydrogel made by KytoGEL is viscous than fibrin glue.
> Stable at room temperature for over one year
> Growth inhibition assay to Escherichia coli, staphylococcus aureus,
Pseudomonas aeruginosa, hay bacillus and Klebsiella pneumoniae
indicates the property of antibacterial that is equal to versatile
> Antivirus function develops through the addition of silver-based
> Endotoxin: Less than 0.2 EU/mg powder*
(ordinary use: 1~2 wt% liquid).
> Cytotoxicity: negative*
> Reverse mutation: negative*
> No serological abnormality (rats)
*Entrusted to Hadano research center institute,
food and drug safety center
> NeTech supplies the raw materials which guaranteed viscosity,
photo-reactivity, pH, and stability.
> KytoGEL is degradable within a month into subcutaneous tissue
(mouse/rat) and submucosa (pig).
> The validity as hemostat, tissue adhesive, wound healing, topical DDS
and the like was proved.
> There are also many clinical study concerning chitosan and a chitosan
“Chitosan preparations for wounds and burns: antimicrobial and
wound healing effects” Tianhong Dai, et al. Expert Rev Anti Infect
Ther. 2011; 9(7): 857–879.
> KytoGEL liquid converts itself into hydrogel through irradiating UV-A within